Montmorillonitin, Canlılarda Kurşunu (Ağır Metal) Etkisizleştirmesi

İngilizce özeti verilen diğer bir çalışmada , Montmorillonitin canlı içinde Ağır Metallerden biri olan Kurşuna İyileştirici Etkileri araştırılmıştır. Deneyde 60 yaban domuzu, her 10’ar adeti eşit ağırlıklarda olacak şekilde rastgele seçilerek 30’lu iki gruba ayrılmıştır. Kontrol grubuna, besininde 10 mg / kg kurşun verilirken, gözlem grubuna ilave olarak besinlerinin % 0.5’i kadar montmorillonit tanecikleri takviye edilmiştir. Yapılan 10 günlük uygulama sonucunda,

Gözlem grubunda yer alan yaban domuzlarının kan, beyin, karaciğer, kemik, böbrek ve saçlarında bulunan kurşun oranlarının, Kontrol grubuna kıyasla ciddi oranlarda az olduğu tespit edilmiştir. Çalışma sonunda, montmorillonit taneciğinin kurşun zehrine karşı, tedavi etkinliğinin olası olduğu belirtilmiştir.

Effects Of Particulate Montmorillonite On Tissue Lead Levels, Erythropoiesis, ALA-D Activity, And Lead- İnduced Lipid Peroxidation İn Liver Of Pigs
Yu Dong-you, Yang Xiao-gang, Xu Zi-rong
Feed Science Institute, Zhejiang University, The Key Laboratory of Molecular Animal Nutrition Ministry of Education, Hangzhou,
Chinese Journal of Veterinary Science, 2006-06
Sixty barrows(Duroc×Labdrace×Yorkshine) were randomly assigned to two groups by weight of 33 kg, each of which was replicated three times with ten pigs. Half of the pigs were fed with diets containing 10 mg/kg lead and 0.5% particulate montmorillonite, the other half pigs were fed only with diets supplemented 10 mg/kg lead as control groups for 100 days. The results showed that the addition of particulate montmorillonite to the diet significantly decreased lead concentration in tissues such as blood,brain,liver,bone,kidney and hair and enhanced the erythropoiesis as measured by increasing numbers of RBC,hemoglobin and hematocrit values, and elevated ALA-D activity in liver. The damage of lead to the liver was evident in the increases in hepatic concentration of malondialdehyde (+17.08%);decreases in the antioxidant enzymes catalase(-85.73%),superoxide dismutase(-52.17%) and glutathione peroxidase(-47.56%).Concomitant use of particulate montmorillonite in the diets completely ameliorated the lead-induced oxidative damage. It indicated that particulate montmorillonite is possessed of the potential therapeutic activity against lead poison.