Montmorillonitin B1 Vitamininde İlaç Taşıyıcı (Drug Carrier) Olarak Kullanılması

B1 Vitamini aynı zamanda Thiamine olarak bilinmektedir. İlk olarak 1926 yılında pirinç kepeğinden ayrıştırılarak elde edilmiş, thiazole ve pyrimidine halkalarından oluşan metilen ile birleşmiş suda çözünebilen bir maddedir. İnsan Vücudu, karbonhidrat, yağ ve protein metabolizmasından önemli bir rol oynar. Kalp ve sinir sisteminin ihtiyaç duyduğu enerjiyi karşılar. İnsan vücudunda B1 eksikliği, vücut sıvıları birikmesine (şişlik), ağrı, felç ve sonuçta ölüme sebebiyet verebilir. Yapılan bir çalışmada B1 vitaminin kontrollü bir biçimde salımının gerçekleşmesi için bir ilaç taşıyıcı olarak montmorillonit üzerinde testler yapılmış, ve çalışma sonunda,

B1 vitaminin kontrollü ilaç salımının gerçekleşmesi için ilaç taşıyıcı (Drug Carrier) olarak Montmorillonitin kullanılabileceği ortaya konmuştur.

Montmorillonite İntercalated With Vitamin B1 As Drug Carrier
Ghanshyam V. Joshi, Hasmukh A. Patel, Bhavesh D. Kevadiya, Hari C. Bajaj
Discipline of Inorganic Materials and Catalysis, Central Salt & Marine Chemicals Research Institute, Council of Scientific and Industrial Research (CSIR), Gijubhai Badheka Marg, Gujarat, India Applied Clay Science 45 (2009) 248–253
Abstract: Vitamin B1 (thiamine hydrochloride, VB1) intercalated into montmorillonite (MMT), which was characterized by X-ray diffraction (XRD), Fourier transformed infrared spectroscopy (FT-IR), and thermo gravimetric analysis (TGA). The adsorption of VB1 on MMT increased with increase in reaction temperature. The adsorption isotherms were fitted by the Langmuir model. About 34 and 64% of the intercalated VB1 was released within 10 h, insimulated gastric fluid (pH 1.2) and simulated intestinal fluid (pH 7.4) respectively at 37±0.5 °C. The release profile of VB1 followed the Higuchi kinetic model and the diffusion-controlled mechanism. During in vitro release experiments VB1 was released from MMT–VB1 steadily as a function of pH.
Conclusion: VB1 was intercalated into MMT by ion exchange. The maximum amount of VB1 intercalated was 23.5 mg/g of MMT at 323K and pH 7 after 1 h of interaction. The intercalation of VB1 into MMT was rapid and equilibrium was observed within 1 h. Adsorption isotherm were fitted by the Langmuir model. Adsorption of VB1 on MMT was spontaneous and endothermic. During in vitro experiments 34% and 64% of VB1 was released from MMT–VB1 in simulated gastric fluid (pH 1.2) and intestinal fluid (pH 7.4). The release followed the Higuchi kinetic model and the Korsmeyer–Peppas model suggested diffusion-controlled release mechanism. The results indicate that MMT can be used as release carrier for VB1.