Bağırsak İltihabı Rahatsızlıklarında Bentonitin Terapisel Etkisi

Bağırsak İltihabı Rahatsızlıklarının ilk safhaları ve bazı tedavi uygulamaları üzerine yazılmış bir bilimsel makalede, yapılan araştırma ve elde edilen bulgular neticesinde;

Montmorillonit-İllit karışımı tabakalanmış Smektit grubu killerin, Bağırsak İltihabı rahatsızlıklarında tedavi olarak bir seçenek olabileceği ve bu modelin epitel yaraların tedavisinde yeni bir bakış açısı sağlayabileceği belirtilmiştir.

Çalışmanın İngilizce özetine aşağıda yer verilmiştir.

Establishment of a novel extracorporeal bowel model to study luminal approaches to treat inflammatory bowel disease.
Breitrück A, Sparmann G, Mitzner S, Kerkhoff C.
University of Rostock, Rostock, Germany;
PMID: 24046362 [PUBMED]  Dis Model Mech. 2013 Sep 18.
We have established an extracorporeal bowel model system for the analysis of early events in inflammatory bowel disease (IBD) and therapeutic applications. This model consists of an intestinal segment that is cannulated and perfused in situ, allowing the investigation of cellular responses of apical mucosa cells on luminal applied substances. Short-term treatment with iodoacetamide mimicked experimental intestinal inflammation in IBD, as indicated by histological alterations such as hemorrhage, hyperemia and loss of regular crypt architecture, as well as enhanced expression of cytokines (e.g. IL-6, IL-10andMCP-1) compared with control segments perfused with media. Perfusion of therapeutic agents (e.g. dexamethasone or Mutaflor) in the small intestine segment significantly reduced the features of early inflammation that are induced by iodoacetamide. Moreover, similar data were obtained for Resormin®, a montmorillonite-illite mixed-layer mineral (smectite), indicating that smectites might be a newly identified therapeutic option for IBD. In summary, this model could provide novel insights into epithelial injury as well as genesis of IBD and, therefore, be useful in testing the therapeutic potential of compounds for IBD therapy.